Sodium pyruvate reduces hypoxic–ischemic injury to neonatal rat brain
نویسندگان
چکیده
منابع مشابه
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Poly(ADP-ribose) synthase (PARS), an abundant nuclear protein, has been described as an important candidate for mediation of neurotoxicity by nitric oxide. However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage. We examined the effect of inhibiting PARS on the (a) degree of cerebral injury, (b) process of inflammatory responses,...
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While hypothermia (HT) is the standard-of-care for neonates with hypoxic ischemic injury (HII), the mechanisms underlying its neuroprotective effect are poorly understood. We examined ischemic core/penumbra and cytokine/chemokine evolution in a 10-day-old rat pup model of HII. Pups were treated for 24 hr after HII with HT (32℃; n = 18) or normothermia (NT, 35℃; n = 15). Outcomes included magnet...
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Objective(s): Infertility in varicocele may have an adverse outcome on the future life of an infertile male. This study was designed to investigate whether varicocele affects remote organs, including the kidney, liver, and brain. We have also evaluated the protective effects of NaHS administration on the structure and function of these organs.Material...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2012
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2012.107